结直肠癌肝转移的相关分子机制

王勇¹, 乌新林²()

¹内蒙古医科大学第一临床学院，呼和浩特 010050
²内蒙古医科大学附属医院胃肠外科，呼和浩特 010050

收稿日期:2025-02-25修回日期:2025-03-19出版日期:2025-06-08发布日期:2025-06-26
通讯作者:乌新林 E-mail:wuxinlin@126.com
基金资助:
内蒙古自治区自然科学基金(2022MS08006)

Related molecular mechanisms of liver metastasis from colorectal cancer

Wang Yong¹, Wu Xinlin²()

¹Affiliated First Clinical College of Inner Mongolia Medical University， Hohhot 010050， China
²Department of Gastrointestinal Surgery， Affiliated Hospital of Inner Mongolia Medical University， Hohhot 010050， China

Received:2025-02-25Revised:2025-03-19Online:2025-06-08Published:2025-06-26
Contact:Wu Xinlin E-mail:wuxinlin@126.com
Supported by:
Natural Science Foundation of Inner Mongolia Autonomous Region of China(2022MS08006)

摘要/Abstract

摘要：

结直肠癌肝转移是一个复杂的生物学过程，涉及多种机制和细胞类型的相互作用，包括肿瘤干细胞性状的自我更新及动态获得；结直肠癌细胞代谢发生特征性改变，以满足转移过程中的能量需求；上皮间质转化促进原位结直肠癌细胞迁移至循环系统成为循环肿瘤细胞，并外渗至门脉系统完成播种、增殖及形成转移灶；肝脏微环境中的驻留细胞和免疫细胞协调免疫反应，诱导转移性肝脏肿瘤的发生。进一步分析结直肠癌肝转移的相关分子机制，以期针对这些分子机制开发新型治疗药物，从而改善患者的预后。

关键词:结直肠肿瘤,肿瘤转移,分子机制

Abstract:

Liver metastasis from colorectal cancer is a complex biological process， involving the interaction of multiple mechanisms and cell types， including the self-renewal and dynamic acquisition of the traits of cancer stem cells. Characteristic metabolic changes occur in colorectal cancer cells to meet the energy demands during the metastasis process. Epithelial-mesenchymal transition promotes the migration of primary colorectal cancer cells into the circulatory system， where they become circulating tumor cells， and then extravasate into the portal venous system to complete the processes of seeding， proliferation， and the formation of metastatic foci. Resident cells and immune cells in the hepatic microenvironment coordinate the immune response， inducing the occurrence of metastatic liver tumors. Further research on the molecular mechanisms related to liver metastasis from colorectal cancer is expected to develop novel therapeutic drugs targeting these molecular mechanisms， so as to improve the prognosis outcomes of patients.

Key words:Colorectal neoplasms,Neoplasm metastasis,Molecular mechanism

王勇, 乌新林. 结直肠癌肝转移的相关分子机制[J]. 国际肿瘤学杂志, 2025, 52(6): 388-391.

Wang Yong, Wu Xinlin. Related molecular mechanisms of liver metastasis from colorectal cancer[J]. Journal of International Oncology, 2025, 52(6): 388-391.

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结直肠癌肝转移的相关分子机制

Related molecular mechanisms of liver metastasis from colorectal cancer

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