Expert consensus on the diagnosis and treatment strategies for advanced esophageal squamous cell carcinoma following progression on first-line immunochemotherapy in Sichuan Province

Abstract

Abstract:

The disease burden of esophageal cancer in China ranks first in the world， with significant regional differences in incidence. Sichuan province is facing a more complicated and severe situation， with a high incidence of esophageal cancer. Although first-line immunotherapy combined with chemotherapy for advanced esophageal squamous cell carcinoma has been widely used clinically， but there is no unified standard and consensus on the treatment of disease progression after immune resistance. The treatment strategy of city-level hospitals is somewhat disordered. In light of this， the Esophageal Cancer Professional Committee of the Sichuan Anti-Cancer Association， in conjunction with multidisciplinary experts in the field of esophageal cancer research in Sichuan province， has developed this consensus. The consensus refers to domestic and foreign guidelines， consensus， and the latest evidence-based clinical evidence， combined with clinical practice experience， with the aim of providing scientific and standardized guidance for clinicians. It is hoped to further improve the treatment outcomes and quality of life for patients with advanced esophageal squamous cell carcinoma and promote the advancement of esophageal cancer diagnosis and treatment in Sichuan province.

Key words:Esophageal squamous cell carcinoma,Immune checkpoint inhibitors,Drug resistance,Disease progression,Treatment strategy,Expert consensus

Esophageal Cancer Professional Committee of the Sichuan Anti-Cancer Association. Expert consensus on the diagnosis and treatment strategies for advanced esophageal squamous cell carcinoma following progression on first-line immunochemotherapy in Sichuan Province[J]. Journal of International Oncology, 2025, 52(5): 273-281.

Figures/Tables2

证据水平	定义
Ⅰ	至少1项方法学质量良好（产生偏倚可能性小）的大规模随机对照试验或对多项没有非均一性且良好实施随机试验的Meta分析提供的证据
Ⅱ	小规模随机试验或怀疑有偏倚（方法学质量较差）的大规模随机试验，或对这些试验或多项有非均一性的试验的Meta分析
Ⅲ	前瞻性队列研究
Ⅳ	回顾性队列研究或病例对照研究
Ⅴ	没有对照组的研究、病理报告、专家观点

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