EGFR基因突变靶向耐药后小细胞肺癌转化的研究进展

摘要/Abstract

摘要：

表皮生长因子受体酪氨酸酶抑制剂（EGFR-TKI）的问世为EGFR基因突变患者带来了福音，不仅可以提高患者的生命质量，而且能够延长多数患者的生存期。但这些患者在服用EGFR-TKI 1年左右便会产生耐药，从而导致疾病进展。EGFR-TKI耐药的机制之一为非小细胞肺癌（NSCLC）转化为小细胞肺癌（SCLC），发生率为2%~14%，是一种较为少见的耐药机制。目前，SCLC转化的机制尚不明确，NSCLC向SCLC转化患者的中位生存期大约为17.8个月。研究EGFR-TKI耐药机制、转化型SCLC发生机制及临床特征，对转化型SCLC的治疗方案及预后具有重要意义。

关键词:EGFR突变,分子靶向治疗,耐药,小细胞肺癌,转化

Abstract:

The advent of epidermal growth factor receptor tyrosine kinase inhibitors （EGFR-TKIs） have brought benefits to patients with EGFR gene mutations， which can not only improve the quality of life of patients， but also prolong their survival. However， most patients develop resistance to EGFR-TKIs after taking them for about one year， leading to disease progression. One of the mechanisms of EGFR-TKIs resistance is the conversion from non-small cell lung cancer （NSCLC） to small cell lung cancer （SCLC）， with an incidence of 2%-14%， which is a relatively rare resistance mechanism. Currently， the mechanism of SCLS transformation remains unclear， and the median survival of patients with NSCLC converted to SCLC is approximately 17.8 months. Studying the resistance mechanism of EGFR-TKIs， the occurrence mechanism and clinical characteristics of transformed SCLC is of great significance for the treatment plan and prognosis of transformed SCLC.

Key words:EGFR mutation,Molecular targeted therapy,Drug resistance,Small cell lung carcinoma,Transformation

赵红晓, 刘春玲. EGFR基因突变靶向耐药后小细胞肺癌转化的研究进展[J]. 国际肿瘤学杂志, 2024, 51(11): 712-716.

Zhao Hongxiao, Liu Chunling. Research progress in the transformation of small cell lung cancer after targeted drug resistance by EGFR gene mutations[J]. Journal of International Oncology, 2024, 51(11): 712-716.

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