CMTM6和CMTM4在肿瘤发生、发展及预后中的作用

国际肿瘤学杂志››2024,Vol. 51››Issue (11): 706-711.doi:10.3760/cma.j.cn371439-20240328-00119

CMTM6和CMTM4在肿瘤发生、发展及预后中的作用

马明珠¹, 高晓玲²()

¹山西医科大学第二临床医学院，太原 030000
²山西医科大学第二医院呼吸与危重症医学科，太原 030000

收稿日期:2024-03-28修回日期:2024-07-12出版日期:2024-11-08发布日期:2024-12-26
通讯作者:高晓玲 E-mail:937658284@qq.com
基金资助:
国家自然科学基金(82370091);山西省卫生健康委员会科技兴医创新计划(2023XM001);山西省科技成果转化引导专项(202204021301068);山西省高等教育“百亿工程”科技引导专项(BYJL029)

Role of CMTM6 and CMTM4 protein in tumorigenesis， development and prognosis

Ma Mingzhu¹, Gao Xiaoling²()

¹Second Clinical Medical College of Shanxi Medical University， Taiyuan 030000， China
²Department of Respiratory and Critical Care Medicine， Second Hospital of Shanxi Medical University， Taiyuan 030000， China

Received:2024-03-28Revised:2024-07-12Online:2024-11-08Published:2024-12-26
Contact:Gao Xiaoling E-mail:937658284@qq.com
Supported by:
National Natural Science Foundation of China(82370091);Shanxi Provincial Health Commission Science and Technology Innovation Program(2023XM001);Shanxi Provincial Science and Technology Achievement Transformation Guidance Project(202204021301068);Shanxi Provincial Higher Education "Ten Billion Project" Science and Technology Guidance Project(BYJL029)

摘要/Abstract

摘要：

含有MARVEL跨膜结构域的趋化样因子基因（CMTM）家族在肿瘤发生、发展、转移和耐药方面起着至关重要的作用。CMTM6和CMTM4是调节程序性死亡受体配体1（PD-L1）稳定性的关键蛋白，尤其在肿瘤免疫治疗耐药性中发挥着重要作用。目前，CMTM6和CMTM4与肿瘤相关的详尽分子机制尚未完全明确。深入研究CMTM4和CMTM6在肿瘤中的表达、生物学作用以及调控机制将为肿瘤的诊断、治疗以及预测预后等方面提供新的思路和靶点。

关键词:CMTM6,CMTM4,肿瘤,耐药性

Abstract:

The CKLF-like MARVEL transmembrane domain containing family of genes （CMTM） family plays a crucial role in tumorigenesis， development， metastasis， and drug resistance. CMTM6 and CMTM4 are key proteins that regulate the stability of programmed death-ligand 1 （PD-L1） and play an important role in tumor immunotherapy resistance in particular. At present， the detailed molecular mechanisms linking CMTM6 and CMTM4 with tumors have not been fully understood. In-depth study of the expression， biological role and regulatory mechanism of CMTM4 and CMTM6 in tumors will provide new ideas and targets for the diagnosis， treatment and prediction of prognosis of tumors.

Key words:CMTM6,CMTM4,Neoplasms,Drug resistance

马明珠, 高晓玲. CMTM6和CMTM4在肿瘤发生、发展及预后中的作用[J]. 国际肿瘤学杂志, 2024, 51(11): 706-711.

Ma Mingzhu, Gao Xiaoling. Role of CMTM6 and CMTM4 protein in tumorigenesis， development and prognosis[J]. Journal of International Oncology, 2024, 51(11): 706-711.

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