微RNA调节癌症恶病质肌萎缩信号通路的研究进展

国际肿瘤学杂志››2025,Vol. 52››Issue (10): 633-636.doi:10.3760/cma.j.cn371439-20241108-00108

微RNA调节癌症恶病质肌萎缩信号通路的研究进展

樊羽羽¹, 贾军梅²()

¹山西医科大学第一临床医学院，太原 030001
²山西医科大学第一医院肿瘤呼吸科，太原 030001

收稿日期:2024-11-08修回日期:2025-09-18出版日期:2025-10-08发布日期:2025-11-12
通讯作者:贾军梅 E-mail:jiajunmei1972@163.com

Research progress on the signaling pathways regulated by microRNAs in cancer cachexia muscle atrophy

Fan Yuyu¹, Jia Junmei²()

¹First Clinical College of Shanxi Medical University， Taiyuan 030001， China
²Department of Respiratory Oncology， First Hospital of Shanxi Medical University， Taiyuan 030001， China

Received:2024-11-08Revised:2025-09-18Online:2025-10-08Published:2025-11-12
Contact:Jia Junmei E-mail:jiajunmei1972@163.com

摘要/Abstract

摘要：

癌症恶病质是一种复杂的多因素疾病，可以导致骨骼肌质量显著下降。微RNA（miRNA）是一种非编码RNA，与癌症恶病质肌萎缩的发展密切相关。研究表明，miRNA通过调控各种信号通路，在癌症恶病质肌萎缩的发生发展中发挥重要作用，但其介导癌症恶病质肌萎缩的机制尚未完全明确。系统探讨miRNA在癌症恶病质肌萎缩中的作用，可为癌症恶病质肌萎缩患者的精准化治疗提供有益参考。

关键词:微RNAs,肿瘤,恶病质,肌萎缩,信号传导

Abstract:

Cancer cachexia is a complex multifactorial disease that can lead to significant reduction of skeletal muscle mass. MicroRNAs （miRNAs） are non-coding RNAs that are closely related to the development of cancer cachexia muscle atrophy. Studies have shown that miRNAs play an important role in the occurrence and development of cancer cachexia muscle atrophy by regulating various signaling pathways， but the mechanism by which miRNAs mediate cancer cachexia muscle atrophy has not been fully clarified. A systematic investigation of the role of miRNAs in cancer cachexia muscle atrophy may provide useful references for the precise treatment of patients with cancer cachexia muscle atrophy.

Key words:MicroRNAs,Neoplasms,Cachexia,Muscle atrophy,Signal transduction

樊羽羽, 贾军梅. 微RNA调节癌症恶病质肌萎缩信号通路的研究进展[J]. 国际肿瘤学杂志, 2025, 52(10): 633-636.

Fan Yuyu, Jia Junmei. Research progress on the signaling pathways regulated by microRNAs in cancer cachexia muscle atrophy[J]. Journal of International Oncology, 2025, 52(10): 633-636.

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