食管癌质子放疗研究进展

摘要/Abstract

摘要：

食管癌是世界范围内肿瘤死亡的主要原因之一，放疗在食管癌的治疗中发挥重要作用，质子放疗由于其独特的生物物理学特性使其较光子放疗在剂量学上可降低危及器官的受量，可能是治疗食管癌的一种理想的放疗方式。在食管癌根治性放疗、新辅助放疗以及再程放疗中，质子放疗均发挥出重要的作用，疗效与光子放疗相当或更优，安全性更有优势。质子放疗与免疫治疗的联合、放疗剂量的提升、基于调强质子放疗技术的大型随机对照研究等将是后续研究的热点。

关键词:食管肿瘤,放射疗法,质子疗法

Abstract:

Esophageal cancer is one of the leading causes of death from cancer worldwide. Radiotherapy plays an important role in the treatment of esophageal cancer. Compared with photon radiotherapy， proton radiotherapy significantly reduces normal organ dose due to its unique biophysical properties， which makes this modality potential ideal for esophageal cancer treatment. Proton radiotherapy plays an important role in radical radiotherapy， neoadjuvant radiotherapy and re-radiotherapy for esophageal cancer. The efficacy is equivalent to or better than that of photon radiotherapy， and proton radiotherapy is superior than photon radiotherapy in security. The combination of proton radiotherapy and immunotherapy， the increase of radiotherapy dose， and large-scale randomized controlled studies based on intensity-modulated proton radiotherapy technology will be hot topics for further research.

Key words:Esophageal neoplasms,Radiotherapy,Proton therapy

付成瑞, 李宝生, 黄伟. 食管癌质子放疗研究进展[J]. 国际肿瘤学杂志, 2025, 52(1): 48-52.

Fu Chengrui, Li Baosheng, Huang Wei. Research progress of proton therapy for esophageal cancer[J]. Journal of International Oncology, 2025, 52(1): 48-52.

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Research progress of proton therapy for esophageal cancer

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