
姓名:卢志远
硕士生导师,博士后合作导师
职称:副教授,泰山学者青年专家,山东高校青创团队负责人
联系方式:luzhiyuan@sdfmu.edu.cn
研究方向:
1.炎症免疫、血液和神经退行性等疾病中药活性成分发现
2.天然先导药物分子靶点鉴定以及药理机制研究
3.中药纳米活性物质发现及中药现代化
主要学术任职:
1.中国药理学会生化与分子药理学专业委员会青年委员
2.山东省研究型医院协会杰出青年学者分会常务委员
3.中国民族医药学会方药量效研究分会理事
4.中国中医药研究促进会免疫疾病分会委员
5.山东中医药学会中医基础理论专业委员会委员
6. Journal of Ginseng Research杂志副主编
7. Chinese Medicine、iMed、Acta Materia Medica、Traditional Medicine Research、Science of Traditional Chinese Medicine、Pharmaceutical Science Advances、Med Research、Pharmacology Discovery和《中医药研究进展》等杂志编委或青年编委
主要获奖情况(包括作为指导教师):
1. 2025年,山东省中药协会青年人才奖
主持科研课题:
1.山东省泰山学者青年专家,2025.01-2027.12,75万,在研。
2.国家自然科学基金青年项目,32300957,磷酸酶PPM1B调控巨噬细胞M1型极化介导溃疡性结肠炎发展的分子机制研究,30万,2024.01-2026.12,在研。
3.山东省自然科学基金青年项目,ZR2023QH427,基于蛋白磷酸酶PPM1B的急性B淋巴细胞白血病治疗新靶标的发现,2024.01-2026.12,15万,在研。
4.山东省高等学校“青创团队计划”,2022KJ197,参麦注射液抗新冠肺炎危重症感染的活性成分及分子机制研究,2023.01-2025.12,30万,在研。
5.山东省医药卫生科技发展计划项目-青年项目,Q-2023107,党参碳量子点的制备、表征及在贫血治疗中的应用,2023.08-2025.07,2万,在研。
6.广东省重点实验室开放课题,5万,2024.01-2025.12,在研
7.百度开云体育app高层次人才引进经费资助项目,2022.07-2027.06,200万,在研。
近五年代表性论文(限第一作者和通讯作者):
1.Zhiyuan Lu#, Lixia Huang#,Yanxia Li, et al.Fine-tuning of cholesterol homeostasis controls erythroid differentiation.Advanced Science. 2021,2102669:1-17. (1区, IF: 17.52)
2.Zhiyuan Lu, Hanzhi Yu, Yanxia Li, et al. Phosphatase, Mg2+/Mn2+ Dependent 1B regulates the hematopoietic stem cells homeostasis via the Wnt/-catenin signaling.Haematologica.2023,109( 7) : 2144-2156. (1区, IF: 10.1)
3.Xiang Li#, Yanjiao Ding#, Jingwen Xue#, Yinxue Fu, Fang Yan, Nannan Song, Honggang Hu, Wei Cong*,Zhiyuan Lu*, Yulei Li*. Peptide Double-Stapling and Arginine N-Glycosylation Triggered the Development of Therapeutic Antimicrobial Peptides Capable of Killing Drug-Resistant Bacteria in Mice.Journal of Medicinal Chemistry. 2025, 68(4): 4511-4526. (1区, IF: 6.8)
4.Zhiyuan Lu*, Haojia Li, Nannan Song, Zhiwei Wang, Hua Wang, Asma Rehman, Liwen Han, Ke-Wu Zeng*. Therapeutic Potential of Carbon Dots Derived from Phytochemicals as Nanozymes Exhibiting Superoxide Dismutase Activity for Anemia. ACS Appl Mater Interfaces. 2025;17(3):4562-4578.(2区, IF:8.6)
5.Zhiyuan Lu#, Guangsen Xu#, Yanxia Li#, et al.Discovery of N-arylcinnamamides as Novel Erythroblast Enucleation Inducers.Bioorganic Chemistry. 2022, 128:106105.(1区, IF: 5.30)
6.Lei Wang#, Zhong-Yao Li#, Chong-Lei Zhong#, Zi-Yang Teng, Bin Wang, Asma Rehman, Li-Wen Han, Ke-Wu Zeng*, Ji-Guo Zhang*,Zhi-Yuan Lu*.Therapeutic potential of naturally derived carbon dots in sepsis-associated acute kidney injury.Chinese medicine. 2025,20(1):49.(2区, IF: 5.30)
7.Zhiyuan Lu, Peng Xiao, Yuan Zhou, et al. Identification of HN252 as a potent inhibitor of protein phosphatase PPM1B.Journal of Cellular and Molecular Medicine. 2020, 00: 1-9. (2区, IF: 5.32)
8.Zhongyao Li, Ruoyu Chen, ……, Kewu Zeng*,Zhiyuan Lu*. A comprehensive overview of PPM1B: From biological functions to diseases.European Journal of Pharmacology. 2023, 947: 175633. (2区, IF: 5.19)
9.Shuai Wang#,Zhiyuan Lu#, Yuxin Wang, et al. Metalloproteins and apolipoprotein C: candidate plasma biomarkers of T2DM screened by comparative proteomics and lipidomics in ZDF rats.Nutrition & Metabolism. 2020, 17: 66. (2区, IF: 4.72)