%A WANG Juan, HU Zhi-Qian %T Research of hepatocyte nuclear factor 4α in digestive system tumors %0 Journal Article %D 2014 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673-422X.2014.12.012 %P 915-918 %V 41 %N 12 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9597.shtml} %8 2014-12-24 %X Hepatocyte nuclear factor 4α is a transcription factor of the nuclear hormone receptor superfamily and plays a very important role in the differentiation and development of the digestive system as well as the polarity regulation, which is considered to be a tumor suppressor gene．It also plays a very important role in digestive tumorigenesis , invasion and metastasis of hepatic carcinoma, colon cancer and gastric cancer, which is closely associated with epithelialtomesenchymal transition, the regulation of cell proliferation and wnt signaling pathway. HNF4α expression and its regulation mechanism in the digestive system tumors are now the research focus.