%A GAO Shan, WANG Ren-Sheng %T Proto-oncogene Bmi-1 and head and neck cancer %0 Journal Article %D 2013 %J Journal of International Oncology %R %P 665-668 %V 40 %N 8 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_9170.shtml} %8 2013-09-08 %X
Bmi-1 is a core member of the polycomb group genes. As a proto-oncogene, Bmi-1 plays an important role in cell self-renewal, proliferation and apoptosis. Several studies have shown that Bmi-1 is highly expressed in some head and neck malignant tumors, such as nasopharyngeal cancer and laryngeal carcinoma. Furthermore, the expression level of Bmi-1 is closely related to the occurrence, development, incursion and prognosis of tumor. Bmi-1 is expected to become a novel tumor molecular marker, and provides a new direction for the treatment of the head and neck malignant tumor.