%A KANG Xiao-Zheng, CHEN Ke-Neng %T Inhibition mechanism of vitamin D in lung cancer %0 Journal Article %D 2012 %J Journal of International Oncology %R %P 594-597 %V 39 %N 8 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_8853.shtml} %8 2012-08-29 %X In recent years a large number of studies have been conducted to investigate the role of vitamin D and its metabolites in cancer. However, the picture for lung cancer is not clear at the present time. There are three integral components of the vitamin D pathway: the vitamin D receptor(VDR), CYP27B1 and CYP24A1. Besides, vitamin D inhibits the carcinogenesis of lung by indirectly influencing IGF signaling, TGF-β signaling, and Wnt/β-catenin signaling pathway. Their differential expressions in normal lung tissue and lung cancer offer clues and lay the foundation for research of the inhibitory function in lung cancer pathogenesis.