%A CHENG Jian, KONG Ling-Ling, LI Hong-Jun, LI Bao-Sheng %T Molecular mechanism of flavonoids for preventing radiationinduced lung injury %0 Journal Article %D 2012 %J Journal of International Oncology %R %P 588-590 %V 39 %N 8 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_8851.shtml} %8 2012-08-29 %X Radiation-induced lung injury is a common complication of thoracic cancer radiotherapy. A lot of animal experiments and clinical studies have shown that ionizing radiationinduced lung injury is a complex process regulated by a variety of cytokines. The transcription factors including nuclear factor κB, MAPK and activator protein-1 are involved in radiation-induced lung injury by regulating the synthesis of a variety of inflammatory proteins. The flavonoids play a role in radiological protection by blocking the pathway of nuclear factor κB and activator protein-1.