%A ZHENG Li-Ping, LI Zhi-Hua, CHEN Ru-Fu %T Nuclear factor-kappa B in epithelial-mesenchymal transition of cancer %0 Journal Article %D 2012 %J Journal of International Oncology %R %P 570-572 %V 39 %N 8 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_8846.shtml} %8 2012-08-29 %X Nuclear factor-kappa B(NF-κB) is a key regulator in epithelialmesenchymal transition(EMT) of cancer cells. EMT of cancer, one of the reasons of drug resistance, enhances the infiltration and distant metastases ability of cancer cells. Recent researches show that Snail, Slug, Twist and Zeb play important roles in regulating EMT of cancer cells. Drugs and targeted therapies that inhibit NFκB activities can reverse the EMT of cancer cells. NFκB may become an effective therapeutic target in cancers in the future.