%A WANG Chao, ZHANG Chu-Yao, FENG Wei-Wei %T Role of Numb in tumors %0 Journal Article %D 2012 %J Journal of International Oncology %R %P 541-544 %V 39 %N 7 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_8837.shtml} %8 2012-08-06 %X Numb, one of the important cell fate determinants, plays a key role in regulation of nerve system development, and it is closely related to the occurrence of tumors. It is proven that Numb is implicated in the processes of occurrence, invasion and metastasis of tumors through regulating the way of cell division, cell polarity, epithelialmesenchymal transitions and several signal pathways, e.g., Notch, Hh, p53. The expression levels of Numb in cells are related to the malignant degree and prognosis of tumors. It is vital to explore the role of Numb in tumors for treating tumors at the standpoint of Numb.