%A MA Dong-Hua, ZHANG Liang, WANG Ya-Xu %T The effect of phosphatidylinositol-3-kinase -protein kinase B signal pathway in colon cancer %0 Journal Article %D 2012 %J Journal of International Oncology %R %P 143-148 %V 39 %N 2 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_8708.shtml} %8 2012-02-08 %X The abnormal activation of phosphatidylinositol-3-kinase (PI3K)-protein kinase B (Akt) pathway has already been confirmed that it is closely related to the origin and development of various tumors. PI3K-Akt pathway plays an important role in development of colon cancer, it can regulate cell survival, proliferation, anti-apoptosis, cell cycle progression, etc. Furthermore, inhibition of this pathway may play a potential roll in oncotherapy.