%A Guo Junlong, Zou Ruiqi, Chen Shaoqiang, Liang Yuxin, Li Jing, Yong Sunan, He Yuting, Xie Xiaobing, Li Ping %T Research progress of RNA m 6A modification in breast cancer %0 Journal Article %D 2025 %J Journal of International Oncology %R 10.3760/cma.j.cn371439-20241203-00090 %P 532-537 %V 52 %N 8 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_11632.shtml} %8 2025-08-08 %X

Breast cancer is one of the most common malignant tumors among women worldwide, with an increasing incidence rate year by year, making it a significant public health concern. With the continuous advancement of tumor biology research, N6-methyladenosine (m6A) modification, as an important form of RNA modification, has attracted growing attention. The m6A modification, the most prevalent RNA modification in eukaryotes, occurs in almost all types of RNA and plays a critical role in the occurrence, progression, and metastasis of breast cancer. It influences cell proliferation, apoptosis, and alterations in the tumor microenvironment, though the specific mechanisms underlying these effects require further in-depth investigation. Moreover, the specific patterns of m6A modification demonstrate its potential as a novel biomarker for breast cancer, which could provide new directions for early diagnosis and prognosis evaluation.

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