The epidermal growth factor receptor （EGFR） exon 20 insertion （ex20ins） mutation is a rare subtype of mutations in non-small cell lung cancer （NSCLC）. Patients with advanced NSCLC carrying the EGFR ex20ins mutation tend to have poor responses to traditional EGFR tyrosine kinase inhibitors （TKIs）， chemotherapy， and immunotherapy， leading to a poor clinical prognosis. Significant progress has been made in the development of new drugs targeting the EGFR ex20ins mutation. The research on new drugs targeting EGFR ex20ins mutations has made significant progress. The main ones include new EGFR-TKIs （such as sunvozertinib， mobocertinib， and furmetinib，etc.）， bispecific antibodies （such as amivantamab， JMT101， and GB263T，etc.）， and emerging drugs such as AUY922. These agents have demonstrated promising efficacy in clinical trials， improving the objective response rate and progression-free survival of patients， and are expected to improve overall survival. An in-depth analysis of the mechanism of action and clinical trial progress of these novel targeted drugs for EGFR ex20ins-mutated NSCLC can offer new therapeutic strategies for patients with EGFR ex20ins-mutated NSCLC.