%A Huang Hai, Bi Feng %T Clinical application of Apatinib in the treatment of malignancies %0 Journal Article %D 2019 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673-422X.2019.01.010 %P 45-48 %V 46 %N 1 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_10576.shtml} %8 2019-01-08 %X Apatinib is a kind of antiangiogenesis drug of small molecular tyrosine kinase inhibitor, which can strongly against tumor angiogenesis by inhibiting vascular endothelial growth factor receptor 2 with highly selectivity. Apatinib can block cell cycle and reverse drug resistance. Clinical studies have shown that Apatinib is effective for many malignant tumors, including non-small-cell lung cancer, breast cancer and gastric cancer, which has encouraging objective response rate and survival benefit. Apatinib also has good safety and tolerance.