%A Xiao Sa, Li Ling, Zhang Mingzhi %T Antitumor effect of histone deacetylase inhibitors %0 Journal Article %D 2017 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673-422X.2017.10.008 %P 754-757 %V 44 %N 10 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_10326.shtml} %8 2017-10-08 %X Histone deacetylase (HDAC) is a kind of protease, which plays an important role in the structural modification of chromosomes and the regulation of gene expression. Its excessive expression in cancer cells causes acetylation imbalance, which is closely related to the occurrence of tumor. The high efficiency and low toxicity of histone deacetylase inhibitor (HDACi) has been widely recognized as antitumor drug with the deepening of the study in epigenetics. It is expected to bring more breakthroughs in the treatment of tumor.