%A Sun Fei, Wang Jianlin, Yu Jingping %T Research advances of cancer therapy targeting HIF-1α-VEGF-VEGFR-2 signaling pathway for malignant tumors %0 Journal Article %D 2017 %J Journal of International Oncology %R 10.3760/cma.j.issn.1673-422X.2017.06.014 %P 456- %V 44 %N 6 %U {https://gjzlx.sdfmu.edu.cn/CN/abstract/article_10235.shtml} %8 2017-06-08 %X Hypoxia inducible factor1α (HIF1α)vascular endothelial growth factor (VEGF)vascular endothelial growth factor receptor2 (VEGFR2) signaling pathway plays a vital role in the regulation of neovascularization, and the activation of this pathway is closely related with tumor invasion and metastasis.