Journal of International Oncology››2013,Vol. 40››Issue (8): 652-655.

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Hypoxia-inducible factor-1 and transforming growth factor-β in tumor

GAO Chao, FENG Xiang-Ying

  1. Department of Neurology, Xinhua Hospital , Dalian University , Dalian 116021, China

  • Online:2013-09-08Published:2013-09-16
  • Contact:Corresponding author: FENG Xiang-ying, E-mail: daiyue315@126.com E-mail:daiyue315@126. com

Abstract:Hypoxia-inducible factor-1 (HIF-1) is one of the most important hypoxia signal transmission factor, and it has been observed in many human tumors. HIF-1 could play a role of promoting tumor by regulating the expression level of transforming growth factor-β in vivo and in vitro, and then affecting the development and prognosis of tumor.

Key words:Hypoxia-inducible factor-1,Transforming growth factor-β,Neoplasms,Vascular endothelial growth factors

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