Abstract:Thyroid hormone is an important hormone for regulating cell differentiation, growth and metabolism. Many studies have shown that thyroid hormone can induce turmor angiogenesis after binding with the integrin ανβ3 receptor at cell surface. Tetraiodothyroacetic acid is the analogue of thyroid hormone, and can inhibit tumor angiogenesis by inhibiting the binding of thyroid hormone with integrin ανβ3. Studying the role of thyroid hormone in promoting tumor angiogenesis may provide a new approach for molecular targeted therapy of tumor.

Key words:Thyroxine,Neoplasms,Targeted therapy